It seems that Count Dracula, in league with a beautiful but diabolical lady scientist, need a simple, pliable brain with which to reactivate Frankenstein's creature. The ideal brain belongs to the hapless Lou Costello, whom the lady doctor woos to gain his confidence and lure him to the operating table. Lawrence Talbot, better known as the Wolf Man, arrives on the scene to warn Costello and his pal Bud Abbott of Dracula's nefarious schemes, but is he too late?